Avondale is a small Chester County borough surrounded by the rolling landscape and agricultural areas of the southern Brandywine Valley. The community sits along Baltimore Pike between Kennett Square and West Grove and is closely connected to the farms, nurseries, and mushroom-growing industry for which this part of Chester County is widely known.

The surrounding area offers convenient access to destinations throughout the Brandywine Valley, including Longwood Gardens, Kennett Square, and communities near the Pennsylvania-Delaware border. Historic properties, open countryside, and working agricultural land contribute to the character of the region. Avondale's location also provides access toward Wilmington and northern Delaware while remaining connected to the communities of southern Chester County.